Head-to-head for women
Direct Meds vs Effecty
Direct Meds and Effecty both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Direct Meds
Ranked #30 for women · Grade B−
Luna Fit
Best for: Women who want an oral or sublingual alternative to weekly shots, on an all-inclusive program with no membership fee, and who are comfortable vetting a newer compounder themselves.
Visit Direct MedsEffecty
Higher scoreRanked #6 for women · Grade B+
Luna Fit
Best for: Women who want the flexibility of both compounded and FDA-approved brand medication from a LegitScript-accredited, nationwide provider.
Visit EffectyThe verdict for women
Effecty edges out Direct Meds on the Luna Fit Score, 87 to 82 (B+ vs B−). Women who want the flexibility of both compounded and FDA-approved brand medication from a LegitScript-accredited, nationwide provider.
Direct Meds is still a genuine option — one of the few programs we track that offers an oral or sublingual route alongside injections — semaglutide drops from about $179 (or $297 injectable), tirzepatide from about $224 — all-inclusive with no separate membership. The trade-off is a newer, less-verified operator whose prices we couldn't confirm live. Weigh the six women's-health factors below against your own priorities.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Direct Meds | Effecty |
|---|---|---|
| Luna Fit Score | 82/100 · B− | 87/100 · B+ |
| Overall rank | #30 | #6 |
| Semaglutide | $179/mo | $160/mo |
| Tirzepatide | $224/mo | $240/mo |
| Coverage | Not publicly listed | All 50 states |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Yes | Injection only |
Luna Fit
Direct Meds
Ranked #30 · Grade B−
What we like
- Rare oral and sublingual route in addition to injectable — a real option for the needle-averse
- Both molecules offered — semaglutide and tirzepatide for insulin-resistant PCOS
- All-inclusive pricing with no separate membership fee, and a promotional entry near $147
The caveats
- Compounded only — no FDA-approved brand semaglutide or tirzepatide
- Prices are company-stated, not ones we could verify live, and the brand runs multiple domains
- A newer operator with an ambiguous footprint, so the oversight signal is thinner
Luna Fit
Effecty
Ranked #6 · Grade B+
What we like
- FDA-approved brand access plus compounded, both molecules
- LegitScript-accredited — a meaningful oversight signal when hormones are involved
- Nationwide across all 50 states
The caveats
- No oral/sublingual form
- Not a hormone-specialty program; PCOS framing is general
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes a Luna Fit Score. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Keep comparing Direct Meds and Effecty against other providers we review for women.
- Direct Meds vs CoreAge Rx
- Direct Meds vs Eden
- Direct Meds vs Ondra Health
- Effecty vs Found
- Effecty vs Vytora Health
- Effecty vs Vaylen
Or browse the full comparison hub.