Is Ozempic or semaglutide approved for PCOS?

No. No GLP-1 medicine — semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) — is FDA-approved to treat polycystic ovary syndrome. Prescribing one for PCOS is off-label: legal, common, and a prescriber's clinical judgment, but not an approved indication, and not something any telehealth provider can change. Approvals for these drugs are for type 2 diabetes and for weight management in people who meet the criteria; many women with PCOS qualify on the weight-management route rather than on a PCOS diagnosis.

Which GLP-1 provider is best for PCOS?

On our published PCOS & hormonal suitability score, Enhance MD leads the ranking at 92/100. That score is our editorial judgment of how well a general GLP-1 program suits someone managing PCOS — whether both molecules are available, whether labs and monitoring are part of the plan, whether hormonal context is handled at all. It is not a finding that any provider specializes in PCOS. Across all 71 providers we score, the factor runs from 92 down to 55, so the best options here is a narrow band rather than a runaway winner.

Semaglutide or tirzepatide for PCOS — does it matter?

Insulin resistance is a central driver for most women with PCOS, which is why tirzepatide — a dual GIP/GLP-1 agonist — comes up so often in this conversation. Practically, it means a provider that only prices semaglutide cannot offer that path at all. Of the 10 providers here, 7 publish a price for both molecules. Neither drug is approved for PCOS, and which one suits you is a clinical decision, not a shopping one.

How is this different from your best GLP-1 for women page?

The women's page is the broad hub: it ranks the same providers on the whole Luna Fit Score, covering perimenopause, contraception, labs and general fit. This page narrows to one published factor — PCOS and hormonal suitability — and ranks on that alone, with no partner edge applied to the order. Start on the women's hub if you are weighing GLP-1 care generally; stay here if PCOS is the reason you are looking.

What about metformin or inositol — do I still need those?

That is a question for your prescriber, not a page like this one. Metformin has a long history in PCOS care and inositol is widely used, and neither is displaced by a GLP-1 simply because a GLP-1 produces more weight loss. What matters here is that a provider is willing to look at your whole picture — labs, cycle, androgens, existing medications — rather than write a prescription and move on. That willingness is a large part of what the suitability score is judging.

Advertising disclosure — We may earn a commission if you start care through some of these links, at no extra cost to you. How we're funded.

PCOS · Ranked · August 2026

The best GLP-1 providers for PCOS, ranked on suitability.

Insulin resistance sits underneath most PCOS weight, which is why these medicines come up so often — and why the provider you pick matters more than usual. We ranked 10 of the 71 programs we score on one published number: PCOS & hormonal suitability.

This is the PCOS-specific page. The broad women's hub is best GLP-1 for women; what the research shows is GLP-1 medication and PCOS.

No GLP-1 is FDA-approved for PCOS.

Semaglutide and tirzepatide are approved for type 2 diabetes and for weight management — not for polycystic ovary syndrome. Using one for PCOS is off-label: a prescriber's clinical judgment, not an approved indication, and no provider on this page can change that. Nothing below says any of these programs specializes in PCOS, treats it, or is approved for it. The ranking reflects our judgment of how well a general GLP-1 program suits someone managing PCOS — and it is not medical advice. Talk to a clinician who knows your history, particularly if you are trying to conceive.

The short answer

Top 10 on PCOS & hormonal suitability

92PCOS
1.
Enhance MD
Highest PCOS score
Overall Luna Fit 92 · All 50 states
Visit
Sema $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepayTirz $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepayHighest PCOS score
90PCOS
2.
CoreAge Rx
Overall Luna Fit 93 · All 50 states
Visit
Sema $99/moTirz $149/mo
89PCOS
3.
Eden
Overall Luna Fit 88 · All 50 states
Visit
Sema $239/moTirz $349/moFDA warning letterJune 2026Read it ↗
89PCOS
4.
Live Vital
Overall Luna Fit 76 · All 50 states claimed
Visit
Sema ~$128/mo ($299 per 10-week protocol; no monthly rate published)Tirz ~$235/mo ($549 per 10-week protocol; no monthly rate published)
89PCOS
5.
NEUVÉ Health
Overall Luna Fit 74 · All 50 states and DC in its own intake map; the same homepage also says members in 40+ states
Visit
Sema $217/mo standard injectable with B12 ($179 microdose, $212 sublingual) — its own financial policy says medication is billed separately, so this may not be an all-in priceTirz $324/mo standard injectable with B12 ($240 microdose, $282 sublingual) — same open question about whether the medication is included
88PCOS
6.
Ro
Overall Luna Fit 86 · Multi-state
Visit
Sema Not disclosedTirz Not disclosed
88PCOS
7.
Telos Rx
Overall Luna Fit 83 · Not publicly listed
Visit
Sema $99/mo injectable — the $49 headline is only the FIRST month of the 12-month prepaid ORAL plan, which renews at $129/mo billed every 48 weeksTirz $139/mo injectable · $129/mo oral · $116/mo microdosed (microdosing is tirzepatide, not semaglutide)
88PCOS
8.
Gala Health
Overall Luna Fit 83 · All 50 states
Visit
Sema $1,299/moTirz $179/mo (yearly plan)
88PCOS
9.
Alloy
Overall Luna Fit 82 · Not disclosed; compounded excluded in 6 states and DC
Visit
Sema From $169/mo all-in ($70 medication + $99 membership)Tirz From $199/mo all-in ($100 medication + $99 membership)
88PCOS
10.
He & She MD
Overall Luna Fit 80 · Every US state except Louisiana for GLP-1s; hormone and longevity lines ship nationwide
Visit
Sema $199/mo month-to-month ($1,188 once for a year is the $99/mo on the banners)Tirz $299/mo month-to-month ($1,908 committed for the year)

Enhance MD tops this site at 92/100 on PCOS & hormonal suitability. Read the band, not just the winner: across all 71 providers we score, the factor runs 92 down to 55, so the difference between the first few rows is genuinely small. 7 of these 10 publish a price for both semaglutide and tirzepatide — worth noticing if insulin resistance is the part you most want addressed.

Order on this page is the published PCOS & hormonal suitability sub-score alone, high to low, ties broken by overall Luna Fit Score. Nothing about who pays us is applied to this order — which is why providers we earn nothing from sit near the top. We may earn a commission if you start care through some of these links, at no extra cost to you. See our disclosure and methodology.

The ranking, provider by provider

Ordered by PCOS & hormonal suitability. Prices are the lowest monthly figure each provider discloses for each molecule; “not disclosed” means exactly that and is never filled in with a guess.

#1
Luna Fit
92/100
Enhance MD
PCOS fit 92Both molecules priced
A tiered compounded program that lays every price on the table — semaglutide, tirzepatide, a microdose lane, and a combo option — with six-month metabolic lab testing and an NAD+ adjacency that speaks to women thinking about metabolism as a whole system.
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Semaglutide:

$249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay
Tirzepatide:

$329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay
States:

All 50 states
Visit Enhance MD Read the full review →
#2
Luna Fit
93/100
CoreAge Rx
PCOS fit 90Both molecules priced
The most reliable on-ramp for women: nationwide access to both molecules at one flat, no-surprise price — including tirzepatide, the option many women with insulin resistance want.
Best for: Women who want transparent flat pricing and dependable nationwide access to both semaglutide and tirzepatide, without a teaser-rate bait-and-switch.
Semaglutide:

$99/mo
Tirzepatide:

$149/mo
States:

All 50 states
Visit CoreAge Rx Read the full review →
#3
Luna Fit
88/100
Eden
PCOS fit 89Both molecules priced
A high-transparency program with unusually clear clinician and supply-chain disclosure — you can see who is prescribing and where the medication comes from, which is rarer than it should be.
Best for: Women who value knowing exactly who is prescribing and where the medication comes from, and will pay above the cheapest tiers for that transparency.
Semaglutide:

$239/mo
Tirzepatide:

$349/mo
States:

All 50 states
Visit Eden Read the full review →
#4
Luna Fit
76/100
Live Vital
PCOS fit 89
A one-physician practice whose founder is menopause-certified and has written a 40-page perimenopause guide — genuine midlife expertise, wrapped around the most misleading price presentation in the ranking.
Best for: Women in perimenopause who want a named, menopause-credentialled physician rather than a clinician network, and who will do the arithmetic on the protocol price themselves.
Semaglutide:

~$128/mo ($299 per 10-week protocol; no monthly rate published)
Tirzepatide:

~$235/mo ($549 per 10-week protocol; no monthly rate published)
States:

All 50 states claimed
Visit Live Vital Read the full review →
#5
Luna Fit
74/100
NEUVÉ Health
PCOS fit 89Both molecules priced
Twelve GLP-1 formulations priced openly before any intake, and the deepest women's testing menu in this ranking — two fertility panels among them. What none of it settles is whether the price includes the drug, a question the seller answers three different ways.
Best for: Women who want hormone, fertility and bone-health panels available beside the prescription, and who will ask the billing line what the monthly figure covers before assuming it covers the medication.
Semaglutide:

$217/mo standard injectable with B12 ($179 microdose, $212 sublingual) — its own financial policy says medication is billed separately, so this may not be an all-in price
Tirzepatide:

$324/mo standard injectable with B12 ($240 microdose, $282 sublingual) — same open question about whether the medication is included
States:

All 50 states and DC in its own intake map; the same homepage also says members in 40+ states
Visit NEUVÉ Health Read the full review →
#6
Luna Fit
86/100
Ro
PCOS fit 88
A heavyweight platform with brand-name (Wegovy/Zepbound) access and insurance navigation — powerful if you want an FDA-approved product, but compounded pricing is opaque.
Best for: Women who want brand-name medication and insurance support, and are comfortable with a big, polished platform.
Semaglutide:

Not disclosed
Tirzepatide:

Not disclosed
States:

Multi-state
Visit Ro Read the full review →
#7
Luna Fit
83/100
Telos Rx
PCOS fit 88Both molecules priced
One of the deepest catalogs we log for a woman managing metabolism and hormones together — semaglutide and tirzepatide in oral, microdosed, and injectable forms, plus bioidentical HRT and a long peptide menu, from a LegitScript-certified, HIPAA-compliant compounder.
Best for: Women who want GLP-1 care under the same roof as bioidentical HRT and needle-free options, from a LegitScript-certified compounder, and who are comfortable vetting a broad menu themselves.
Semaglutide:

$99/mo injectable — the $49 headline is only the FIRST month of the 12-month prepaid ORAL plan, which renews at $129/mo billed every 48 weeks
Tirzepatide:

$139/mo injectable · $129/mo oral · $116/mo microdosed (microdosing is tirzepatide, not semaglutide)
States:

Not publicly listed
Visit Telos Rx Read the full review →
#8
Luna Fit
83/100
Gala Health
PCOS fit 88Both molecules priced
A GLP-1 program built explicitly for women — its product pages say so, and it sells HRT and menopause care beside the weight-loss line, which is a genuine draw if you are managing metabolism and hormones together. The $179 entry is real, but it is a yearly-subscription rate; no month-to-month price is published.
Best for: Women who want compounded tirzepatide and hormone care from one provider, are comfortable committing to a year to get the advertised rate, and value having a brand-Ozempic escape hatch.
Semaglutide:

$1,299/mo
Tirzepatide:

$179/mo (yearly plan)
States:

All 50 states
Visit Gala Health Read the full review →
#9
Luna Fit
82/100
Alloy
PCOS fit 88
The only program in this ranking built for midlife first: your prescriber is a Menopause Society–certified physician, and weight care sits alongside a full hormone-therapy line rather than being sold in isolation.
Best for: Women in perimenopause or menopause who want the clinician managing their weight to be the same one who understands their hormones — and who can absorb a membership fee on top of the drug price.
Semaglutide:

From $169/mo all-in ($70 medication + $99 membership)
Tirzepatide:

From $199/mo all-in ($100 medication + $99 membership)
States:

Not disclosed; compounded excluded in 6 states and DC
Visit Alloy Read the full review →
#10
Luna Fit
80/100
He & She MD
PCOS fit 88Both molecules priced
The one desk here that also sells the menopause side — estradiol as a patch, a gel or a pill plus progesterone — under the same intake as its GLP-1s, and the only line on the site whose price has no term table behind it.
Best for: Women who want the GLP-1 and the hormone conversation handled by one clinician rather than split across two providers, and who will read the asterisk before choosing a plan length.
Semaglutide:

$199/mo month-to-month ($1,188 once for a year is the $99/mo on the banners)
Tirzepatide:

$299/mo month-to-month ($1,908 committed for the year)
States:

Every US state except Louisiana for GLP-1s; hormone and longevity lines ship nationwide
Visit He & She MD Read the full review →

Showing the top 10 of 71. The rest of the field is on the main ranking, or compare any two head-to-head.

What “PCOS & hormonal suitability” actually measures

It is one of the six factors behind every Luna Fit Score, and it is our editorial judgment — not a provider's claim about itself, and not a clinical rating of a drug. Broadly it asks whether a general GLP-1 program can hold the parts of PCOS care that go beyond a prescription:

Access to both molecules. Tirzepatide is frequently the one asked about where insulin resistance drives the weight, so a semaglutide-only menu is a real limitation — see semaglutide vs tirzepatide for women.
Labs and monitoring as part of the plan, not an upsell. What is worth measuring, and when, is in GLP-1 labs and monitoring for women.
Whether hormonal context is handled at all — cycles, androgens, contraception timing around a slowed gut. Background in GLP-1s and insulin resistance and GLP-1s and birth control.
Continuity. PCOS is managed over years, so cancellation terms and ongoing support matter more than a first-month price. How we weigh all six factors is set out in our published methodology.

What it is not: a finding that any provider runs a PCOS clinic, employs a reproductive endocrinologist, or treats PCOS as an indication. None of that is in our roster, so none of it is claimed here.

GLP-1s and PCOS, answered

Is Ozempic or semaglutide approved for PCOS?: No. No GLP-1 medicine — semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) — is FDA-approved to treat polycystic ovary syndrome. Prescribing one for PCOS is off-label: legal, common, and a prescriber's clinical judgment, but not an approved indication, and not something any telehealth provider can change. Approvals for these drugs are for type 2 diabetes and for weight management in people who meet the criteria; many women with PCOS qualify on the weight-management route rather than on a PCOS diagnosis.
Which GLP-1 provider is best for PCOS?: On our published PCOS & hormonal suitability score, Enhance MD leads the ranking at 92/100. That score is our editorial judgment of how well a general GLP-1 program suits someone managing PCOS — whether both molecules are available, whether labs and monitoring are part of the plan, whether hormonal context is handled at all. It is not a finding that any provider specializes in PCOS. Across all 71 providers we score, the factor runs from 92 down to 55, so the best options here is a narrow band rather than a runaway winner.
Semaglutide or tirzepatide for PCOS — does it matter?: Insulin resistance is a central driver for most women with PCOS, which is why tirzepatide — a dual GIP/GLP-1 agonist — comes up so often in this conversation. Practically, it means a provider that only prices semaglutide cannot offer that path at all. Of the 10 providers here, 7 publish a price for both molecules. Neither drug is approved for PCOS, and which one suits you is a clinical decision, not a shopping one.
How is this different from your best GLP-1 for women page?: The women's page is the broad hub: it ranks the same providers on the whole Luna Fit Score, covering perimenopause, contraception, labs and general fit. This page narrows to one published factor — PCOS and hormonal suitability — and ranks on that alone, with no partner edge applied to the order. Start on the women's hub if you are weighing GLP-1 care generally; stay here if PCOS is the reason you are looking.
What about metformin or inositol — do I still need those?: That is a question for your prescriber, not a page like this one. Metformin has a long history in PCOS care and inositol is widely used, and neither is displaced by a GLP-1 simply because a GLP-1 produces more weight loss. What matters here is that a provider is willing to look at your whole picture — labs, cycle, androgens, existing medications — rather than write a prescription and move on. That willingness is a large part of what the suitability score is judging.

Keep reading: what the evidence shows on GLP-1s and PCOS, how to choose a provider, what it costs and how to start safely, or perimenopause and menopause if that is also in the picture.

This page is informational and not medical advice. GLP-1 medicines are not FDA-approved for PCOS and any such use is off-label; compounded medications are not FDA-approved brand products. Do not use these medicines in pregnancy or while trying to conceive. See our medical disclaimer.

The best GLP-1 providers for PCOS, ranked on suitability.

Top 10 on PCOS & hormonal suitability

The ranking, provider by provider

Enhance MD

CoreAge Rx

Eden

Live Vital

NEUVÉ Health

Ro

Telos Rx

Gala Health

Alloy

He & She MD

What “PCOS & hormonal suitability” actually measures

GLP-1s and PCOS, answered