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PCOS · Ranked · July 2026

The best GLP-1 providers for PCOS, ranked on suitability.

Insulin resistance sits underneath most PCOS weight, which is why these medicines come up so often — and why the provider you pick matters more than usual. We ranked 10 of the 35 programs we score on one published number: PCOS & hormonal suitability.

This is the PCOS-specific page. The broad women's hub is best GLP-1 for women; what the research shows is GLP-1 medication and PCOS.

No GLP-1 is FDA-approved for PCOS.

Semaglutide and tirzepatide are approved for type 2 diabetes and for weight management — not for polycystic ovary syndrome. Using one for PCOS is off-label: a prescriber's clinical judgement, not an approved indication, and no provider on this page can change that. Nothing below says any of these programs specialises in PCOS, treats it, or is approved for it. The ranking reflects our judgement of how well a general GLP-1 program suits someone managing PCOS — and it is not medical advice. Talk to a clinician who knows your history, particularly if you are trying to conceive.

The short answer

Top 10 on PCOS & hormonal suitability

  1. 1.

    CoreAge Rx

    Overall Luna Fit 93 · All 50 states

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    Sema $149/moTirz $349/moHighest PCOS score
  2. 2.

    Eden

    Overall Luna Fit 91 · All 50 states

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    Sema $239/moTirz $349/mo
  3. 3.

    Gala Health

    Overall Luna Fit 86 · All 50 states

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    Sema $1,299/moTirz $179/mo
  4. 4.

    Ro

    Overall Luna Fit 86 · Multi-state

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    Sema Not disclosedTirz Not disclosed
  5. 5.

    Telos Rx

    Overall Luna Fit 85 · Not publicly listed

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    Sema From $49/mo (microdosed)Tirz From $99/mo (annual)
  6. 6.

    Vytora Health

    Overall Luna Fit 87 · All 50 states

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    Sema $150/moTirz $200/mo
  7. 7.

    AgelessRx

    Overall Luna Fit 85 · Not disclosed

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    Sema $139/moTirz Not disclosed
  8. 8.

    Effecty

    Overall Luna Fit 87 · All 50 states

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    Sema $160/moTirz $240/mo
  9. 9.

    Vaylen

    Overall Luna Fit 87 · All 50 states

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    Sema $179/moTirz $239/mo
  10. 10.

    HealthRX

    Overall Luna Fit 86 · Not publicly listed

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    Sema $189/moTirz $349/mo

CoreAge Rx tops this board at 90/100 on PCOS & hormonal suitability. Read the band, not just the winner: across all 35 providers we score, the factor runs 90 down to 72, so the difference between the first few rows is genuinely small. 7 of these 10 publish a price for both semaglutide and tirzepatide — worth noticing if insulin resistance is the part you most want addressed.

Order on this page is the published PCOS & hormonal suitability sub-score alone, high to low, ties broken by overall Luna Fit Score. The capped 3-point edge affiliate partners carry in list order on our main board is not applied here — which is why providers we earn nothing from sit near the top. We may earn a commission if you start care through some of these links, at no extra cost to you. See our disclosure and methodology.

The ranking, provider by provider

Ordered by PCOS & hormonal suitability. Prices are the lowest monthly figure each provider discloses for each molecule; “not disclosed” means exactly that and is never filled in with a guess.

  1. #1

    CoreAge Rx

    PCOS fit 90Both molecules priced

    The most reliable on-ramp for women: nationwide access to both molecules at one flat, no-surprise price — including tirzepatide, the option many women with insulin resistance want.

    Best for: Women who want transparent flat pricing and dependable nationwide access to both semaglutide and tirzepatide, without a teaser-rate bait-and-switch.

    Semaglutide:
    $149/mo
    Tirzepatide:
    $349/mo
    States:
    All 50 states
    Visit CoreAge Rx Read the full review →
  2. #2

    Eden

    PCOS fit 89Both molecules priced

    A high-touch, high-disclosure program — the strongest clinical oversight and lab framing among the providers we review, which matters when hormones are in play.

    Best for: Women who want a vetted, high-transparency provider with clinician involvement and labs over the lowest sticker price.

    Semaglutide:
    $239/mo
    Tirzepatide:
    $349/mo
    States:
    All 50 states
    Visit Eden Read the full review →
  3. #3

    Gala Health

    PCOS fit 88Both molecules priced

    One of the lowest compounded-tirzepatide entry points we log — from $179, or $149 for a microdose — paired with a rare all-50-states footprint and an optional brand path. The adjacent HRT and menopause line is a genuine draw for women managing metabolism and hormones together.

    Best for: Women who want a low-cost compounded tirzepatide on-ramp nationwide, value having a brand-Ozempic escape hatch, and appreciate a provider that also treats the hormone side through its HRT and menopause line.

    Semaglutide:
    $1,299/mo
    Tirzepatide:
    $179/mo
    States:
    All 50 states
    Visit Gala Health Read the full review →
  4. #4

    Ro

    PCOS fit 88

    A heavyweight platform with brand-name (Wegovy/Zepbound) access and insurance navigation — powerful if you want an FDA-approved product, but compounded pricing is opaque.

    Best for: Women who want brand-name medication and insurance support, and are comfortable with a big, polished platform.

    Semaglutide:
    Not disclosed
    Tirzepatide:
    Not disclosed
    States:
    Multi-state
    Visit Ro Read the full review →
  5. #5

    Telos Rx

    PCOS fit 88

    One of the deepest catalogs we log for a woman managing metabolism and hormones together — semaglutide and tirzepatide in oral, microdosed, and injectable forms, plus bioidentical HRT and a long peptide menu, from a LegitScript-certified, HIPAA-compliant compounder.

    Best for: Women who want GLP-1 care under the same roof as bioidentical HRT and needle-free options, from a LegitScript-certified compounder, and who are comfortable vetting a broad menu themselves.

    Semaglutide:
    From $49/mo (microdosed)
    Tirzepatide:
    From $99/mo (annual)
    States:
    Not publicly listed
    Visit Telos Rx Read the full review →
  6. #6

    Vytora Health

    PCOS fit 87Both molecules priced

    One of the few accredited programs pairing FDA-approved brand access with compounded on both molecules, nationwide — reassuring when you want a real clinical path for hormonal metabolic care.

    Best for: Women who want the option of FDA-approved brand medication alongside compounded, from a LegitScript-accredited, all-50-states provider.

    Semaglutide:
    $150/mo
    Tirzepatide:
    $200/mo
    States:
    All 50 states
    Visit Vytora Health Read the full review →
  7. #7

    AgelessRx

    PCOS fit 87

    A longevity-leaning brand whose hormone and healthy-aging catalog speaks directly to the perimenopause transition — plus some of the lower semaglutide pricing.

    Best for: Women in the perimenopause/menopause transition who want GLP-1 care alongside a longevity- and hormone-aware program.

    Semaglutide:
    $139/mo
    Tirzepatide:
    Not disclosed
    States:
    Not disclosed
    Visit AgelessRx Read the full review →
  8. #8

    Effecty

    PCOS fit 86Both molecules priced

    An accredited, brand-capable program with mid-market pricing on both molecules — a balanced pick when you want FDA-approved options on the table alongside compounded.

    Best for: Women who want the flexibility of both compounded and FDA-approved brand medication from a LegitScript-accredited, nationwide provider.

    Semaglutide:
    $160/mo
    Tirzepatide:
    $240/mo
    States:
    All 50 states
    Visit Effecty Read the full review →
  9. #9

    Vaylen

    PCOS fit 86Both molecules priced

    One of the most complete feature sets we review for women: both molecules, an oral option, FDA-approved brand access, and LegitScript accreditation, all nationwide.

    Best for: Women who want maximum optionality — injectable or oral, compounded or brand — from an accredited, all-50-states provider.

    Semaglutide:
    $179/mo
    Tirzepatide:
    $239/mo
    States:
    All 50 states
    Visit Vaylen Read the full review →
  10. #10

    HealthRX

    PCOS fit 86Both molecules priced

    A LegitScript-certified, physician-supervised program with a rare oral GLP-1 tablet alongside injections — both molecules, transparent no-insurance pricing, and an accreditation signal that reassures when hormones are in play.

    Best for: Women who want a LegitScript-certified, physician-supervised program with both molecules, an oral-tablet route as well as injections, and transparent flat pricing with no insurance to navigate.

    Semaglutide:
    $189/mo
    Tirzepatide:
    $349/mo
    States:
    Not publicly listed
    Visit HealthRX Read the full review →

Showing the top 10 of 35. The rest of the field is on the main board, or compare any two head-to-head.

What “PCOS & hormonal suitability” actually measures

It is one of the six factors behind every Luna Fit Score, and it is our editorial judgement — not a provider's claim about itself, and not a clinical rating of a drug. Broadly it asks whether a general GLP-1 program can hold the parts of PCOS care that go beyond a prescription:

What it is not: a finding that any provider runs a PCOS clinic, employs a reproductive endocrinologist, or treats PCOS as an indication. None of that is in our roster, so none of it is claimed here.

GLP-1s and PCOS, answered

Is Ozempic or semaglutide approved for PCOS?
No. No GLP-1 medicine — semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) — is FDA-approved to treat polycystic ovary syndrome. Prescribing one for PCOS is off-label: legal, common, and a prescriber's clinical judgement, but not an approved indication, and not something any telehealth provider can change. Approvals for these drugs are for type 2 diabetes and for weight management in people who meet the criteria; many women with PCOS qualify on the weight-management route rather than on a PCOS diagnosis.
Which GLP-1 provider is best for PCOS?
On our published PCOS & hormonal suitability score, CoreAge Rx leads the board at 90/100. That score is our editorial judgement of how well a general GLP-1 program suits someone managing PCOS — whether both molecules are available, whether labs and monitoring are part of the plan, whether hormonal context is handled at all. It is not a finding that any provider specialises in PCOS. Across all 35 providers we score, the factor runs from 90 down to 72, so the top of this board is a narrow band rather than a runaway winner.
Semaglutide or tirzepatide for PCOS — does it matter?
Insulin resistance is a central driver for most women with PCOS, which is why tirzepatide — a dual GIP/GLP-1 agonist — comes up so often in this conversation. Practically, it means a provider that only prices semaglutide cannot offer that path at all. Of the 10 providers on this board, 7 publish a price for both molecules. Neither drug is approved for PCOS, and which one suits you is a clinical decision, not a shopping one.
How is this different from your best GLP-1 for women page?
The women's page is the broad hub: it ranks the same providers on the whole Luna Fit Score, covering perimenopause, contraception, labs and general fit. This page narrows to one published factor — PCOS and hormonal suitability — and ranks on that alone, with no partner edge applied to the order. Start on the women's hub if you are weighing GLP-1 care generally; stay here if PCOS is the reason you are looking.
What about metformin or inositol — do I still need those?
That is a question for your prescriber, not a page like this one. Metformin has a long history in PCOS care and inositol is widely used, and neither is displaced by a GLP-1 simply because a GLP-1 produces more weight loss. What matters here is that a provider is willing to look at your whole picture — labs, cycle, androgens, existing medications — rather than write a prescription and move on. That willingness is a large part of what the suitability score is judging.

Keep reading: what the evidence shows on GLP-1s and PCOS, how to choose a provider, what it costs and how to start safely, or perimenopause and menopause if that is also in the picture.

This page is informational and not medical advice. GLP-1 medicines are not FDA-approved for PCOS and any such use is off-label; compounded medications are not FDA-approved brand products. Do not use these medicines in pregnancy or while trying to conceive. See our medical disclaimer.