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Head-to-head for women

System Labs vs Sesame Care

System Labs and Sesame Care both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.

System Labs

Ranked #18 for women · Grade B−

Best for: Women who want one predictable monthly cost that does not climb as they titrate, and who are comfortable with a single compounded GLP-1/GIP injection rather than a choice of named molecules.

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vs

Sesame Care

Higher score

Ranked #4 for women · Grade B

Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

Visit Sesame Care

The verdict for women

Higher Luna Fit Score: Sesame Care

Sesame Care edges out System Labs on the Luna Fit Score, 85 to 81 (B vs B−). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

System Labs is still a genuine option — a flat $179 a month at every dose, with the ongoing rate stated in writing rather than buried under an intro price — and you can cancel from your own dashboard, which is more than most of this board will commit to. Weigh the six women's-health factors below against your own priorities.

Side-by-side on the six factors

Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.

System Labs Sesame Care
PCOS & hormonal suitability7884
System
Sesame
Clinical oversight & labs8288
System
Sesame
Price transparency8480
System
Sesame
Nationwide access7492
System
Sesame
Ongoing support8482
System
Sesame
Cancellation fairness8885
System
Sesame

Price, access & features

DetailSystem LabsSesame Care
Luna Fit Score81/100 · B−85/100 · B
Overall rank#18#4
SemaglutideNot disclosedFrom $149/mo (brand Wegovy pill)
TirzepatideGLP-1/GIP $179/mo flat ($99 first month)Brand Zepbound (price varies)
CoverageNot publicly listedNationwide marketplace
Brand-name accessCompounded onlyYes
Oral / sublingualInjection onlyYes

System Labs

Ranked #18 · Grade B−

What we like

  • One flat price at every dose — the plan is sold as a "Monthly Supply (All doses)", so titrating up does not quietly raise the bill
  • The ongoing rate is stated, not implied: their own FAQ says the subscription is billed at a flat $179/mo with no hidden fees
  • Pause or cancel yourself from the dashboard at any time — no phone call, no retention queue

The caveats

  • Compounded medication is not FDA-approved, and the site says so plainly in its own FDA disclosure
  • The molecule is never named — it is sold only as "compounded GLP-1/GIP", so you cannot compare it against a semaglutide or tirzepatide price anywhere else on this board
  • The headline price is a first-month teaser: $99 for month one against a $179 standing rate, so budget for $179 rather than the number in the hero
Visit System Labs Full review →

Sesame Care

Ranked #4 · Grade B

What we like

  • Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
  • Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
  • You choose the provider and see the price up front — genuine marketplace transparency

The caveats

  • A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
  • Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
  • Brand-name cash prices can run high without insurance
Visit Sesame Care Full review →

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

More head-to-heads

Keep comparing System Labs and Sesame Care against other providers we review for women.

Or browse the full comparison hub.