Head-to-head for women
Direct Meds vs Enhance MD
Direct Meds and Enhance MD both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Direct Meds
Ranked #26 for women · Grade B−
Luna Fit
Best for: Women who want an oral or sublingual alternative to weekly shots, on an all-inclusive program with no membership fee, and who are comfortable vetting a newer compounder themselves.
FDA warning letterSeptember 2025Read it ↗Visit Direct MedsEnhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDThe verdict for women
Enhance MD edges out Direct Meds on the Luna Fit Score, 92 to 80 (A− vs B−). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
Direct Meds is still a genuine option — one of the few programs we track that offers an oral or sublingual route alongside injections — semaglutide drops from about $179 (or $297 injectable), tirzepatide from about $224 — all-inclusive with no separate membership. The trade-off is a newer, less-verified operator whose prices we couldn't confirm live. Weigh the six women's-health factors below against your own priorities; what we found reviewing Direct Meds goes through each of them, and if neither of these two is the one, the full field we rank against Direct Meds widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Direct Meds | Enhance MD |
|---|---|---|
| Luna Fit Score | 80/100 · B− | 92/100 · A− |
| Overall rank | #26 | #2 |
| Semaglutide | $249/mo sublingual · $297/mo injectable | $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay |
| Tirzepatide | $299/mo sublingual · $399/mo injectable | $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay |
| Coverage | Not publicly listed | All 50 states |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Injection only |
Luna Fit
Direct Meds
Ranked #26 · Grade B−
What we like
- Rare oral and sublingual route in addition to injectable — a real option for the needle-averse
- Both molecules offered — semaglutide and tirzepatide for insulin-resistant PCOS
- All-inclusive pricing with no separate membership fee, and a promotional entry near $147
The caveats
- Compounded only — no FDA-approved brand semaglutide or tirzepatide
- Prices are company-stated, not ones we could verify live, and the brand runs multiple domains
- A newer operator with an ambiguous footprint, so the oversight signal is thinner
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Direct Meds nor Enhance MD is only worth comparing with the other. Direct Meds is also written up against CoreAge Rx, 13 points apart on the Luna Fit Score — see Direct Meds vs CoreAge Rx for women. Enhance MD is also written up against CoreAge Rx, 1 point apart — see the Enhance MD–CoreAge Rx head-to-head.
- Direct Meds vs CoreAge Rx
- Direct Meds vs yourEra
- Direct Meds vs Sesame Care
- Enhance MD vs HealthRX
- Enhance MD vs MadeMed
- Enhance MD vs Trimi
Or browse the full comparison hub.