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Head-to-head for women
Direct Meds vs HealthRX
Direct Meds and HealthRX both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Direct Meds
Ranked #26 for women · Grade B−
Luna Fit
Best for: Women who want an oral or sublingual alternative to weekly shots, on an all-inclusive program with no membership fee, and who are comfortable vetting a newer compounder themselves.
FDA warning letterSeptember 2025Read it ↗Visit Direct MedsHealthRX
Higher scoreRanked #6 for women · Grade B
Luna Fit
Best for: Women who want a LegitScript-certified, physician-supervised program with both molecules, an oral-tablet route as well as injections, and transparent flat pricing with no insurance to navigate.
Visit HealthRXThe verdict for women
HealthRX edges out Direct Meds on the Luna Fit Score, 85 to 80 (B vs B−). Women who want a LegitScript-certified, physician-supervised program with both molecules, an oral-tablet route as well as injections, and transparent flat pricing with no insurance to navigate. The reasoning behind that number is in the HealthRX scorecard.
Direct Meds is still a genuine option — one of the few programs we track that offers an oral or sublingual route alongside injections — semaglutide drops from about $179 (or $297 injectable), tirzepatide from about $224 — all-inclusive with no separate membership. The trade-off is a newer, less-verified operator whose prices we couldn't confirm live. Weigh the six women's-health factors below against your own priorities; what we found reviewing Direct Meds goes through each of them, and if neither of these two is the one, the full field we rank against Direct Meds widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Direct Meds | HealthRX |
|---|---|---|
| Luna Fit Score | 80/100 · B− | 85/100 · B |
| Overall rank | #26 | #6 |
| Semaglutide | $249/mo sublingual · $297/mo injectable | $190/mo month-to-month ($99 first month, renews at $165) · $99/mo on a 12-month prepay ($1,188) |
| Tirzepatide | $299/mo sublingual · $399/mo injectable | $239/mo month-to-month ($149 first month, renews at $214) · $179/mo on a 12-month prepay ($2,148) |
| Coverage | Not publicly listed | Not publicly listed |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Yes | Yes |
Luna Fit
Direct Meds
Ranked #26 · Grade B−
What we like
- Rare oral and sublingual route in addition to injectable — a real option for the needle-averse
- Both molecules offered — semaglutide and tirzepatide for insulin-resistant PCOS
- All-inclusive pricing with no separate membership fee, and a promotional entry near $147
The caveats
- Compounded only — no FDA-approved brand semaglutide or tirzepatide
- Prices are company-stated, not ones we could verify live, and the brand runs multiple domains
- A newer operator with an ambiguous footprint, so the oversight signal is thinner
Luna Fit
HealthRX
Ranked #6 · Grade B
What we like
- LegitScript-certified (a meaningful third-party trust signal) with physician-supervised care, not a prescription-only handoff
- Both molecules plus a rare oral GLP-1 tablet — real optionality for the needle-averse and for insulin-resistant PCOS
- Transparent, no-insurance flat pricing — injectable GLP-1 around $189/mo, oral tablet around $239/mo, GLP+GIP around $349/mo
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- Some tiers are company-stated and the public site is thin, so a few figures can't be verified live
- Brand-name tiers are pass-through and expensive — brand Ozempic runs about $1,299/mo
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Direct Meds nor HealthRX is only worth comparing with the other. Direct Meds is also written up against CoreAge Rx, 13 points apart on the Luna Fit Score — see Direct Meds vs CoreAge Rx for women. HealthRX is also written up against CoreAge Rx, 8 points apart — see the HealthRX–CoreAge Rx head-to-head.
- Direct Meds vs CoreAge Rx
- Direct Meds vs Enhance MD
- Direct Meds vs Eden
- HealthRX vs yourEra
- HealthRX vs Sesame Care
- HealthRX vs MadeMed
Or browse the full comparison hub.