Head-to-head for women
Enhance MD vs He & She MD
Enhance MD and He & She MD both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Enhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDHe & She MD
Ranked #25 for women · Grade B−
Luna Fit
Best for: Women who want the GLP-1 and the hormone conversation handled by one clinician rather than split across two providers, and who will read the asterisk before choosing a plan length.
Visit He & She MDThe verdict for women
Enhance MD edges out He & She MD on the Luna Fit Score, 92 to 80 (A− vs B−). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
He & She MD is still a genuine option — the one desk here that also sells the menopause side — estradiol as a patch, a gel or a pill plus progesterone — under the same intake as its GLP-1s, and the only line on the site whose price has no term table behind it. Weigh the six women's-health factors below against your own priorities; the He & She MD scorecard goes through each of them, and if neither of these two is the one, our ranked shortlist of He & She MD alternatives widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Enhance MD | He & She MD |
|---|---|---|
| Luna Fit Score | 92/100 · A− | 80/100 · B− |
| Overall rank | #2 | #25 |
| Semaglutide | $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay | $199/mo month-to-month ($1,188 once for a year is the $99/mo on the banners) |
| Tirzepatide | $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay | $299/mo month-to-month ($1,908 committed for the year) |
| Coverage | All 50 states | Every US state except Louisiana for GLP-1s; hormone and longevity lines ship nationwide |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Yes |
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Luna Fit
He & She MD
Ranked #25 · Grade B−
What we like
- Sells estradiol (patch, gel and pill) and progesterone alongside its GLP-1s, so the menopause and metabolic sides run through one intake
- Prices four commitment terms per GLP-1 molecule in public, with the amount actually charged printed beside each
- Names the dispensing pharmacy in full — F&F Pharmacies Inc, doing business as Jungle Jim's Pharmacy, 5484 Dixie Highway, Fairfield OH 45014, with a phone number
The caveats
- ⚠ The menopause line is the one place it stops publishing terms: estradiol patch, gel and pill and the progesterone pill all show "Starting at $125/month" with no term table at all, while seven other product pages carry a full four-rung ladder
- ⚠ Every advertised GLP-1 figure is the twelve-month rung — the "$99/month" on the banners requires $1,188 paid once, and the rate you can stop after a month is $199
- Its FAQ says the pharmacy it names is licensed in 44 states and cannot dispense sterile compounds; a weekly GLP-1 injection is a sterile compound, and a second pharmacy is named in the same answer without saying which fills what
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Enhance MD nor He & She MD is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. He & She MD is also written up against CoreAge Rx, 13 points apart — see He & She MD against CoreAge Rx, factor by factor.
- Enhance MD vs CoreAge Rx
- Enhance MD vs yourEra
- Enhance MD vs Sesame Care
- He & She MD vs HealthRX
- He & She MD vs MadeMed
- He & She MD vs Trimi
Or browse the full comparison hub.