Head-to-head for women
Enhance MD vs SkinnyRx
Enhance MD and SkinnyRx both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Enhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDSkinnyRx
Ranked #51 for women · Grade C
Luna Fit
Best for: Readers treating insulin resistance who want the dual GIP/GLP-1 molecule without a weekly injection, and who will open the plan selector and read the month-to-month rate rather than the advertised one.
FDA warning letterFebruary 2026Read it ↗Visit SkinnyRxThe verdict for women
Enhance MD edges out SkinnyRx on the Luna Fit Score, 92 to 71 (A− vs C). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
SkinnyRx is still a genuine option — the rare program that compounds tirzepatide as a dissolving tablet as well as an injection — genuinely useful if the needle is what is stopping you — sold behind a four-rung commitment ladder whose cheapest rung is the only price the site ever shows you. Weigh the six women's-health factors below against your own priorities; the SkinnyRx scorecard goes through each of them, and if neither of these two is the one, our ranked shortlist of SkinnyRx alternatives widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Enhance MD | SkinnyRx |
|---|---|---|
| Luna Fit Score | 92/100 · A− | 71/100 · C |
| Overall rank | #2 | #51 |
| Semaglutide | $212/mo | $349/mo month-to-month (from $199/mo on a 12-month plan) — the site displays only the 12-month rate |
| Tirzepatide | $280/mo | $399/mo month-to-month, injectable or dissolving tablet (from $299/mo on a 12-month plan) — the site displays only the 12-month rate |
| Coverage | All 50 states | No state list published; the offer terms report no state restrictions |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Yes |
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Luna Fit
SkinnyRx
Ranked #51 · Grade C
What we like
- A compounded tirzepatide TABLET — a dissolving sublingual route for the dual GIP/GLP-1 molecule, priced identically to the injection at every rung, which is close to unique in this ranking
- Both molecules across three routes — injection, sublingual and daily tablet — so needle aversion never means changing provider or dropping back to the single-pathway drug
- Lower-dose "microdose" lines for both molecules are sold as their own products with their own published ladders, rather than being quoted at the full-dose price
The caveats
- Carries an active FDA warning letter issued in February 2026 (see the notice on this page for FDA's own record)
- Every price the site advertises is the TWELVE-MONTH rung: its own headline reads "Starting at $299/mo" while the month-to-month tirzepatide rate is $399 and the renewal price in its code is literally 399 — semaglutide is the same shape at $199 advertised against $349 month-to-month
- The commitment is not named beside the number anywhere in the marketing copy, and the prepay rung is also what its schema.org product markup publishes as the price — so search engines and AI assistants are given the twelve-month rate as though it were the monthly one
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Enhance MD nor SkinnyRx is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. SkinnyRx is also written up against CoreAge Rx, 22 points apart — see the SkinnyRx–CoreAge Rx head-to-head.
- Enhance MD vs CoreAge Rx
- Enhance MD vs yourEra
- Enhance MD vs Sesame Care
- SkinnyRx vs HealthRX
- SkinnyRx vs MadeMed
- SkinnyRx vs Trimi
Or browse the full comparison hub.