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Head-to-head for women

Sesame Care vs Enhance MD

Sesame Care and Enhance MD both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.

Sesame Care

Ranked #5 for women · Grade B

Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

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vs

Enhance MD

Higher score

Ranked #2 for women · Grade A−

Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.

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The verdict for women

Higher Luna Fit Score: Enhance MD

Enhance MD edges out Sesame Care on the Luna Fit Score, 92 to 85 (A− vs B). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.

Sesame Care is still a genuine option — an established national telehealth marketplace with the widest real brand-name GLP-1 access on the board — Wegovy (pen and pill), Zepbound, Ozempic and Mounjaro — plus provider-by-provider price transparency. Weigh the six women's-health factors below against your own priorities.

Side-by-side on the six factors

Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.

Sesame Care Enhance MD
PCOS & hormonal suitability8492
Sesame
Enhance
Clinical oversight & labs8894
Sesame
Enhance
Price transparency8094
Sesame
Enhance
Nationwide access9295
Sesame
Enhance
Ongoing support8288
Sesame
Enhance
Cancellation fairness8585
Sesame
Enhance

Price, access & features

DetailSesame CareEnhance MD
Luna Fit Score85/100 · B92/100 · A−
Overall rank#5#2
SemaglutideFrom $149/mo (brand Wegovy pill)$212/mo
TirzepatideBrand Zepbound (price varies)$280/mo
CoverageNationwide marketplaceAll 50 states
Brand-name accessYesCompounded only
Oral / sublingualYesInjection only

Sesame Care

Ranked #5 · Grade B

What we like

  • Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
  • Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
  • You choose the provider and see the price up front — genuine marketplace transparency

The caveats

  • A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
  • Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
  • Brand-name cash prices can run high without insurance

Enhance MD

Ranked #2 · Grade A−

What we like

  • Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
  • Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
  • Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff

The caveats

  • Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
  • No brand-name path and no oral or sublingual route for the needle-averse
  • Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes a Luna Fit Score; affiliate partners carry a capped 6-point edge in list order, never in the score itself. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

More head-to-heads

Keep comparing Sesame Care and Enhance MD against other providers we review for women.

Or browse the full comparison hub.