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Head-to-head for women

Synergy Rx vs Sesame Care

Synergy Rx and Sesame Care both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.

Synergy Rx

Ranked #38 for women · Grade C

Best for: Women who specifically want a brand-name path and unlimited clinical contact, and who are prepared to get pricing by enquiry.

Visit Synergy Rx
vs

Sesame Care

Higher score

Ranked #5 for women · Grade B

Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

Visit Sesame Care

The verdict for women

Higher Luna Fit Score: Sesame Care

Sesame Care edges out Synergy Rx on the Luna Fit Score, 85 to 76 (B vs C). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

Synergy Rx is still a genuine option — one of the few programmes here that will prescribe brand-name Wegovy, Ozempic or Mounjaro when clinically appropriate, with unlimited 24/7 access to its clinical team — though you will not find a GLP-1 price anywhere on its site. Weigh the six women's-health factors below against your own priorities.

Side-by-side on the six factors

Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.

Synergy Rx Sesame Care
PCOS & hormonal suitability8084
Synergy
Sesame
Clinical oversight & labs8288
Synergy
Sesame
Price transparency5880
Synergy
Sesame
Nationwide access7492
Synergy
Sesame
Ongoing support9082
Synergy
Sesame
Cancellation fairness7085
Synergy
Sesame

Price, access & features

DetailSynergy RxSesame Care
Luna Fit Score76/100 · C85/100 · B
Overall rank#38#5
SemaglutideFrom $199/moFrom $149/mo (brand Wegovy pill)
TirzepatideFrom $349/moBrand Zepbound (price varies)
CoverageNot disclosedNationwide marketplace
Brand-name accessYesYes
Oral / sublingualInjection onlyYes

Synergy Rx

Ranked #38 · Grade C

What we like

  • Will prescribe FDA-approved brand-name Wegovy, Ozempic or Mounjaro when clinically appropriate — rare on this board
  • Unlimited appointments, messaging and 24/7 access to a dedicated clinical team
  • FSA and HSA eligible

The caveats

  • Publishes no GLP-1 price on its own site — the longevity line is priced openly, the medication this page is about is not
  • At $349/mo, tirzepatide sits roughly $100 above the compounded median we track
  • Does not publish which states it serves

Sesame Care

Ranked #5 · Grade B

What we like

  • Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
  • Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
  • You choose the provider and see the price up front — genuine marketplace transparency

The caveats

  • A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
  • Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
  • Brand-name cash prices can run high without insurance

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes a Luna Fit Score; affiliate partners carry a capped 6-point edge in list order, never in the score itself. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

More head-to-heads

Keep comparing Synergy Rx and Sesame Care against other providers we review for women.

Or browse the full comparison hub.