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Head-to-head for women
Direct Meds vs He & She MD
Direct Meds and He & She MD both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Direct Meds
Ranked #26 for women · Grade B−
Luna Fit
Best for: Women who want an oral or sublingual alternative to weekly shots, on an all-inclusive program with no membership fee, and who are comfortable vetting a newer compounder themselves.
FDA warning letterSeptember 2025Read it ↗Visit Direct MedsHe & She MD
Ranked #25 for women · Grade B−
Luna Fit
Best for: Women who want the GLP-1 and the hormone conversation handled by one clinician rather than split across two providers, and who will read the asterisk before choosing a plan length.
Visit He & She MDThe verdict for women
Direct Meds and He & She MD tie on the Luna Fit Score at 80/100 apiece, so neither runs away with it. The right pick comes down to the factors that matter most to you — compare them below, or read what we found reviewing Direct Meds and the He & She MD scorecard in full. If the answer is still neither, the full field we rank against Direct Meds widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Direct Meds | He & She MD |
|---|---|---|
| Luna Fit Score | 80/100 · B− | 80/100 · B− |
| Overall rank | #26 | #25 |
| Semaglutide | $249/mo sublingual · $297/mo injectable | $199/mo month-to-month ($1,188 once for a year is the $99/mo on the banners) |
| Tirzepatide | $299/mo sublingual · $399/mo injectable | $299/mo month-to-month ($1,908 committed for the year) |
| Coverage | Not publicly listed | Every US state except Louisiana for GLP-1s; hormone and longevity lines ship nationwide |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Yes | Yes |
Luna Fit
Direct Meds
Ranked #26 · Grade B−
What we like
- Rare oral and sublingual route in addition to injectable — a real option for the needle-averse
- Both molecules offered — semaglutide and tirzepatide for insulin-resistant PCOS
- All-inclusive pricing with no separate membership fee, and a promotional entry near $147
The caveats
- Compounded only — no FDA-approved brand semaglutide or tirzepatide
- Prices are company-stated, not ones we could verify live, and the brand runs multiple domains
- A newer operator with an ambiguous footprint, so the oversight signal is thinner
Luna Fit
He & She MD
Ranked #25 · Grade B−
What we like
- Sells estradiol (patch, gel and pill) and progesterone alongside its GLP-1s, so the menopause and metabolic sides run through one intake
- Prices four commitment terms per GLP-1 molecule in public, with the amount actually charged printed beside each
- Names the dispensing pharmacy in full — F&F Pharmacies Inc, doing business as Jungle Jim's Pharmacy, 5484 Dixie Highway, Fairfield OH 45014, with a phone number
The caveats
- The menopause line is the one place it stops publishing terms: estradiol patch, gel and pill and the progesterone pill all show "Starting at $125/month" with no term table at all, while seven other product pages carry a full four-rung ladder
- Every advertised GLP-1 figure is the twelve-month rung — the "$99/month" on the banners requires $1,188 paid once, and the rate you can stop after a month is $199
- Its FAQ says the pharmacy it names is licensed in 44 states and cannot dispense sterile compounds; a weekly GLP-1 injection is a sterile compound, and a second pharmacy is named in the same answer without saying which fills what
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Direct Meds nor He & She MD is only worth comparing with the other. Direct Meds is also written up against CoreAge Rx, 13 points apart on the Luna Fit Score — see Direct Meds vs CoreAge Rx for women. He & She MD is also written up against CoreAge Rx, 13 points apart — see He & She MD against CoreAge Rx, factor by factor.
- Direct Meds vs CoreAge Rx
- Direct Meds vs Enhance MD
- Direct Meds vs Eden
- He & She MD vs yourEra
- He & She MD vs Sesame Care
- He & She MD vs HealthRX
Or browse the full comparison hub.