Advertising disclosure — We may earn a commission if you start care through some of these links, at no extra cost to you. How we're funded. Order reflects our editorial rubric and our commercial relationships; scores are ours alone.
Head-to-head for women
Enhance MD vs Rx.com
Enhance MD and Rx.com both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Enhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDRx.com
Ranked #55 for women · Grade C
Luna Fit
Best for: A woman who does not want a subscription that re-bills itself, and who values knowing which pharmacy dispenses over paying the lowest sticker.
Visit Rx.comThe verdict for women
Enhance MD edges out Rx.com on the Luna Fit Score, 92 to 77 (A− vs C). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
Rx.com is still a genuine option — the fairest cancellation terms of anything reviewed here — "No automatic renewals" is printed on the plan card — from a company that also names the pharmacy filling the vial. Weigh the six women's-health factors below against your own priorities; the Rx.com scorecard goes through each of them, and if neither of these two is the one, our ranked shortlist of Rx.com alternatives widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Enhance MD | Rx.com |
|---|---|---|
| Luna Fit Score | 92/100 · A− | 77/100 · C |
| Overall rank | #2 | #55 |
| Semaglutide | $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay | $175/mo month-to-month ($146 only on a six-month prepay) |
| Tirzepatide | $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay | $285/mo month-to-month ($259 only on a six-month prepay) |
| Coverage | All 50 states | 49 states on its plan page; its own banner says all 50 |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Luna Fit
Rx.com
Ranked #55 · Grade C
What we like
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
The caveats
- The advertised "$146/mo FOR LIFE" is a six-month prepay on semaglutide; month-to-month tirzepatide is $285
- The plan page says 49 states served while the banner on the same site says all 50
- No lab or monitoring protocol is published, and nothing addresses PCOS or the perimenopause transition
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Enhance MD nor Rx.com is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. Rx.com is also written up against CoreAge Rx, 16 points apart — see the Rx.com–CoreAge Rx head-to-head.
- Enhance MD vs CoreAge Rx
- Enhance MD vs Eden
- Enhance MD vs yourEra
- Rx.com vs Sesame Care
- Rx.com vs HealthRX
- Rx.com vs MadeMed
Or browse the full comparison hub.