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Head-to-head for women
Rx.com vs Sesame Care
Rx.com and Sesame Care both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Rx.com
Ranked #55 for women · Grade C
Luna Fit
Best for: A woman who does not want a subscription that re-bills itself, and who values knowing which pharmacy dispenses over paying the lowest sticker.
Visit Rx.comSesame Care
Higher scoreRanked #5 for women · Grade B
Luna Fit
Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.
Visit Sesame CareThe verdict for women
Sesame Care edges out Rx.com on the Luna Fit Score, 85 to 77 (B vs C). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program. The reasoning behind that number is in the Sesame Care scorecard.
Rx.com is still a genuine option — the fairest cancellation terms of anything reviewed here — "No automatic renewals" is printed on the plan card — from a company that also names the pharmacy filling the vial. Weigh the six women's-health factors below against your own priorities; the Rx.com scorecard goes through each of them, and if neither of these two is the one, our ranked shortlist of Rx.com alternatives widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Rx.com | Sesame Care |
|---|---|---|
| Luna Fit Score | 77/100 · C | 85/100 · B |
| Overall rank | #55 | #5 |
| Semaglutide | $175/mo month-to-month ($146 only on a six-month prepay) | Brand Wegovy pill from $149/mo at 1.5 and 4 mg only, $299/mo at 9 and 25 mg — plus Sesame care: $59/mo only on the 12-month prepay, otherwise $99 billed every 28 days (13 charges a year) |
| Tirzepatide | $285/mo month-to-month ($259 only on a six-month prepay) | Brand Zepbound vial $299/mo (2.5 mg), $399 (5 mg), $449 (7.5–15 mg); KwikPen $299 / $399 / $499 / $699 (10–15 mg) — plus Sesame care: $59/mo on the 12-month prepay, otherwise $99 per 28 days |
| Coverage | 49 states on its plan page; its own banner says all 50 | Nationwide marketplace |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Injection only | Yes |
Luna Fit
Rx.com
Ranked #55 · Grade C
What we like
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
The caveats
- The advertised "$146/mo FOR LIFE" is a six-month prepay on semaglutide; month-to-month tirzepatide is $285
- The plan page says 49 states served while the banner on the same site says all 50
- No lab or monitoring protocol is published, and nothing addresses PCOS or the perimenopause transition
Luna Fit
Sesame Care
Ranked #5 · Grade B
What we like
- Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
- Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
- You choose the provider and see the price up front — genuine marketplace transparency
The caveats
- A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
- Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
- Brand-name cash prices can run high without insurance
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Rx.com nor Sesame Care is only worth comparing with the other. Rx.com is also written up against CoreAge Rx, 16 points apart on the Luna Fit Score — see the Rx.com–CoreAge Rx head-to-head. Sesame Care is also written up against CoreAge Rx, 8 points apart — see Sesame Care against CoreAge Rx, factor by factor.
- Rx.com vs CoreAge Rx
- Rx.com vs Enhance MD
- Rx.com vs Eden
- Sesame Care vs yourEra
- Sesame Care vs HealthRX
- Sesame Care vs MadeMed
Or browse the full comparison hub.