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Head-to-head for women
Sesame Care vs System Labs
Sesame Care and System Labs both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Sesame Care
Higher scoreRanked #5 for women · Grade B
Luna Fit
Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.
Visit Sesame CareSystem Labs
Ranked #18 for women · Grade B−
Luna Fit
Best for: Women who want one predictable monthly cost that does not climb as they titrate, and who are comfortable with a single compounded GLP-1/GIP injection rather than a choice of named molecules.
Visit System LabsThe verdict for women
Sesame Care edges out System Labs on the Luna Fit Score, 85 to 81 (B vs B−). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program. The reasoning behind that number is in the Sesame Care scorecard.
System Labs is still a genuine option — a flat $179 a month at every dose, with the ongoing rate stated in writing rather than buried under an intro price — and you can cancel from your own dashboard, which is more than most of this ranking will commit to. Weigh the six women's-health factors below against your own priorities; our System Labs write-up for women goes through each of them, and if neither of these two is the one, the alternatives to System Labs we rank for women widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Sesame Care | System Labs |
|---|---|---|
| Luna Fit Score | 85/100 · B | 81/100 · B− |
| Overall rank | #5 | #18 |
| Semaglutide | Brand Wegovy pill from $149/mo at 1.5 and 4 mg only, $299/mo at 9 and 25 mg — plus Sesame care: $59/mo only on the 12-month prepay, otherwise $99 billed every 28 days (13 charges a year) | Not offered — the one GLP-1 product is a compounded GLP-1/GIP and no semaglutide is sold |
| Tirzepatide | Brand Zepbound vial $299/mo (2.5 mg), $399 (5 mg), $449 (7.5–15 mg); KwikPen $299 / $399 / $499 / $699 (10–15 mg) — plus Sesame care: $59/mo on the 12-month prepay, otherwise $99 per 28 days | GLP-1/GIP $179/mo flat ($99 first month) |
| Coverage | Nationwide marketplace | Not publicly listed |
| Brand-name access | Yes | Compounded only |
| Oral / sublingual | Yes | Injection only |
Luna Fit
Sesame Care
Ranked #5 · Grade B
What we like
- Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
- Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
- You choose the provider and see the price up front — genuine marketplace transparency
The caveats
- A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
- Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
- Brand-name cash prices can run high without insurance
Luna Fit
System Labs
Ranked #18 · Grade B−
What we like
- One flat price at every dose — the plan is sold as a "Monthly Supply (All doses)", so titrating up does not quietly raise the bill
- The ongoing rate is stated, not implied: their own FAQ says the subscription is billed at a flat $179/mo with no hidden fees
- Pause or cancel yourself from the dashboard at any time — no phone call, no retention queue
The caveats
- Compounded medication is not FDA-approved, and the site says so plainly in its own FDA disclosure
- The molecule is never named — it is sold only as "compounded GLP-1/GIP", so you cannot compare it against a semaglutide or tirzepatide price anywhere else in this ranking
- The headline price is a first-month teaser: $99 for month one against a $179 standing rate, so budget for $179 rather than the number in the hero
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Sesame Care nor System Labs is only worth comparing with the other. Sesame Care is also written up against CoreAge Rx, 8 points apart on the Luna Fit Score — see Sesame Care against CoreAge Rx, factor by factor. System Labs is also written up against CoreAge Rx, 12 points apart — see the System Labs–CoreAge Rx head-to-head.
- Sesame Care vs CoreAge Rx
- Sesame Care vs Enhance MD
- Sesame Care vs Eden
- System Labs vs yourEra
- System Labs vs HealthRX
- System Labs vs MadeMed
Or browse the full comparison hub.