Head-to-head for women
Enhance MD vs NewSelf
Enhance MD and NewSelf both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Enhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDNewSelf
Ranked #54 for women · Grade C
Luna Fit
Best for: Women who are certain they want three months of a flat-priced compounded GLP-1 and will not need to change their mind, because changing it is expensive here.
Visit NewSelfThe verdict for women
Enhance MD edges out NewSelf on the Luna Fit Score, 92 to 64 (A− vs C). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
NewSelf is still a genuine option — one price at any dose, three months of medication shipped up front — and a set of exit terms and unresolved compliance problems that make it the hardest program on this board to leave. Weigh the six women's-health factors below against your own priorities; our NewSelf write-up for women goes through each of them, and if neither of these two is the one, our ranked shortlist of NewSelf alternatives widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Enhance MD | NewSelf |
|---|---|---|
| Luna Fit Score | 92/100 · A− | 64/100 · C |
| Overall rank | #2 | #54 |
| Semaglutide | $212/mo | $134.99/mo flat at every dose (as low as $99.97; 3-month term required) |
| Tirzepatide | $280/mo | $224.99/mo flat at every dose (as low as $144.49; 3-month term required) |
| Coverage | All 50 states | 48 states and Puerto Rico (not Mississippi or Louisiana) |
| Brand-name access | Compounded only | Compounded only |
| Oral / sublingual | Injection only | Injection only |
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Luna Fit
NewSelf
Ranked #54 · Grade C
What we like
- One flat price at every dose for both molecules, with the dose ladder published beside it
- Three months of medication shipped up front, so there is no waiting on refills mid-titration
- LegitScript certified with a published, checkable ID
The caveats
- FDA warning letter MARCS-CMS 721472, dated 20 February 2026, to NewSelf Limited dba NewSelf, over product labelling and marketing language. As of 1 August 2026 the wording the FDA objected to was still live on the site — five months on, unremediated
- The product pages carry a badge reading 'cancel anytime', while the refund policy requires a three-month commitment and charges a full retail month as an early-cancellation fee. Those cannot both be true
- No refunds: cancelling before the doctor's review costs a $99 administrative fee, and after it nothing is refundable regardless of shipment status
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Enhance MD nor NewSelf is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. NewSelf is also written up against CoreAge Rx, 29 points apart — see the NewSelf–CoreAge Rx head-to-head.
- Enhance MD vs CoreAge Rx
- Enhance MD vs yourEra
- Enhance MD vs Sesame Care
- NewSelf vs HealthRX
- NewSelf vs Strut Health
- NewSelf vs MadeMed
Or browse the full comparison hub.