Head-to-head for women
Enhance MD vs RxSpan MD
Enhance MD and RxSpan MD both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
Enhance MD
Higher scoreRanked #2 for women · Grade A−
Luna Fit
Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.
Visit Enhance MDRxSpan MD
Ranked #19 for women · Grade B−
Luna Fit
Best for: Women who want to be able to check the pharmacy and the prescriber before they buy, and who may want to move between compounded, oral and brand-name options on one account — provided they pick the Monthly plan themselves rather than accepting the prepay the funnel has already selected.
Visit RxSpan MDThe verdict for women
Enhance MD edges out RxSpan MD on the Luna Fit Score, 92 to 81 (A− vs B−). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.
RxSpan MD is still a genuine option — one of the very few programs here that will tell you who compounds your medication and who signs the prescription — four pharmacies named with phone numbers, two physicians named with NPIs that resolve — wrapped around a full menu that runs from compounded semaglutide to brand Zepbound. Weigh the six women's-health factors below against your own priorities; our RxSpan MD write-up for women goes through each of them, and if neither of these two is the one, the full field we rank against RxSpan MD widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | Enhance MD | RxSpan MD |
|---|---|---|
| Luna Fit Score | 92/100 · A− | 81/100 · B− |
| Overall rank | #2 | #19 |
| Semaglutide | $249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepay | $249/mo month-to-month (3/6/12-month prepay: $219/$199/$194 per month, billed $657/$1,194/$2,327 up front) |
| Tirzepatide | $329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepay | $329/mo month-to-month (3/6/12-month prepay: $309/$289/$269 per month, billed $927/$1,734/$3,228 up front) |
| Coverage | All 50 states | All 50 states |
| Brand-name access | Compounded only | Yes |
| Oral / sublingual | Injection only | Yes |
Luna Fit
Enhance MD
Ranked #2 · Grade A−
What we like
- Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
- Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
- Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff
The caveats
- Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
- No brand-name path and no oral or sublingual route for the needle-averse
- Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Luna Fit
RxSpan MD
Ranked #19 · Grade B−
What we like
- Four dispensing pharmacies named outright, with phone numbers — Belmar, Strive, Epiq Scripts and Casa Pharma Rx — where most of this ranking says only "our partner pharmacies"
- The prescribing group is named too, and checkable: Lion MD, led by Dr Ana Lisa Carr, MD (NPI 1689841744) with Dr Kelly Tenbrink, MD (NPI 1346482684). Both resolve as active physicians in the federal NPPES registry
- A real brand-name lane with prices on the page rather than an enquiry form — Ozempic $1,299, Wegovy $1,349 and Zepbound $1,069 a month — alongside the compounded line, so switching does not mean switching provider
The caveats
- The plan selector arrives with the 3-month prepay already chosen, not Monthly, and badges the 3-, 6- and 12-month tiers alike as "Max Saving" — so the default path takes $657 up front rather than $249, and the headline figures are footnoted "(For the first month)"
- Its FAQ says "no long-term commitments" on the same site where the 12-month semaglutide plan is a single $2,327 charge and the 12-month tirzepatide plan is $3,228. The freedom is real on the monthly plan; it is not what the prepay tiers are
- Brand-name bundles carry a $50 medical review fee if a clinician does not end up prescribing for you — worth knowing before you start an intake for Wegovy or Zepbound
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither Enhance MD nor RxSpan MD is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. RxSpan MD is also written up against CoreAge Rx, 12 points apart — see the RxSpan MD–CoreAge Rx head-to-head.
- Enhance MD vs CoreAge Rx
- Enhance MD vs yourEra
- Enhance MD vs Sesame Care
- RxSpan MD vs HealthRX
- RxSpan MD vs MadeMed
- RxSpan MD vs Trimi
Or browse the full comparison hub.