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Head-to-head for women

Enhance MD vs System Labs

Enhance MD and System Labs both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.

Enhance MD

Higher score

Ranked #2 for women · Grade A−

Best for: Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes.

Visit Enhance MD
vs

System Labs

Ranked #18 for women · Grade B−

Best for: Women who want one predictable monthly cost that does not climb as they titrate, and who are comfortable with a single compounded GLP-1/GIP injection rather than a choice of named molecules.

Visit System Labs

The verdict for women

Higher Luna Fit Score: Enhance MD

Enhance MD edges out System Labs on the Luna Fit Score, 92 to 81 (A− vs B−). Women who want fully transparent tiered pricing — including a microdose entry and a combo option — plus recurring metabolic lab work, and who don't need brand-name or oral routes. The reasoning behind that number is in the Enhance MD scorecard.

System Labs is still a genuine option — a flat $179 a month at every dose, with the ongoing rate stated in writing rather than buried under an intro price — and you can cancel from your own dashboard, which is more than most of this ranking will commit to. Weigh the six women's-health factors below against your own priorities; our System Labs write-up for women goes through each of them, and if neither of these two is the one, the alternatives to System Labs we rank for women widens the field.

Side-by-side on the six factors

Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.

Enhance MD System Labs
PCOS & hormonal suitability9278
Enhance
System
Clinical oversight & labs9482
Enhance
System
Price transparency9484
Enhance
System
Nationwide access9574
Enhance
System
Ongoing support8884
Enhance
System
Cancellation fairness8588
Enhance
System

Price, access & features

DetailEnhance MDSystem Labs
Luna Fit Score92/100 · A−81/100 · B−
Overall rank#2#18
Semaglutide$249 every 4 weeks month-to-month (13 charges a year); $212/mo only on the 12-month prepayNot offered — the one GLP-1 product is a compounded GLP-1/GIP and no semaglutide is sold
Tirzepatide$329 every 4 weeks month-to-month (13 charges a year); $280/mo only on the 12-month prepayGLP-1/GIP $179/mo flat ($99 first month)
CoverageAll 50 statesNot publicly listed
Brand-name accessCompounded onlyCompounded only
Oral / sublingualInjection onlyInjection only

Enhance MD

Ranked #2 · Grade A−

What we like

  • Unusually transparent tiered pricing — semaglutide $212/mo (first month $112), tirzepatide $280/mo, microdose $169/mo, and a combo option at $322/mo
  • Dose-flat billing, so a titration up doesn't quietly raise your monthly cost
  • Six-month metabolic lab testing with provider oversight — a real clinical loop, not a prescription-only handoff

The caveats

  • Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
  • No brand-name path and no oral or sublingual route for the needle-averse
  • Licensed in all 50 states, though their own FAQ lists product as launched in 40 plus DC so far — worth confirming your state before you start
Visit Enhance MD Full review →

System Labs

Ranked #18 · Grade B−

What we like

  • One flat price at every dose — the plan is sold as a "Monthly Supply (All doses)", so titrating up does not quietly raise the bill
  • The ongoing rate is stated, not implied: their own FAQ says the subscription is billed at a flat $179/mo with no hidden fees
  • Pause or cancel yourself from the dashboard at any time — no phone call, no retention queue

The caveats

  • Compounded medication is not FDA-approved, and the site says so plainly in its own FDA disclosure
  • The molecule is never named — it is sold only as "compounded GLP-1/GIP", so you cannot compare it against a semaglutide or tirzepatide price anywhere else in this ranking
  • The headline price is a first-month teaser: $99 for month one against a $179 standing rate, so budget for $179 rather than the number in the hero
Visit System Labs Full review →

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

More head-to-heads

Neither Enhance MD nor System Labs is only worth comparing with the other. Enhance MD is also written up against CoreAge Rx, 1 point apart on the Luna Fit Score — see the Enhance MD–CoreAge Rx head-to-head. System Labs is also written up against CoreAge Rx, 12 points apart — see the System Labs–CoreAge Rx head-to-head.

Or browse the full comparison hub.