Head-to-head for women
RxSpan MD vs Sesame Care
RxSpan MD and Sesame Care both offer GLP-1 telehealth to women, but they make different trade-offs on PCOS and hormonal suitability, clinical oversight, price and access. Here they are side-by-side on the Luna Fit Score — our women's-health rubric.
RxSpan MD
Ranked #19 for women · Grade B−
Luna Fit
Best for: Women who want to be able to check the pharmacy and the prescriber before they buy, and who may want to move between compounded, oral and brand-name options on one account — provided they pick the Monthly plan themselves rather than accepting the prepay the funnel has already selected.
Visit RxSpan MDSesame Care
Higher scoreRanked #4 for women · Grade B
Luna Fit
Best for: Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.
Visit Sesame CareThe verdict for women
Sesame Care edges out RxSpan MD on the Luna Fit Score, 85 to 81 (B vs B−). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program. The reasoning behind that number is in the Sesame Care scorecard.
RxSpan MD is still a genuine option — one of the very few programs here that will tell you who compounds your medication and who signs the prescription — four pharmacies named with phone numbers, two physicians named with NPIs that resolve — wrapped around a full menu that runs from compounded semaglutide to brand Zepbound. Weigh the six women's-health factors below against your own priorities; our RxSpan MD write-up for women goes through each of them, and if neither of these two is the one, the full field we rank against RxSpan MD widens the field.
Side-by-side on the six factors
Both providers scored on the same women's-health rubric — the higher side on each factor is marked. See the methodology.
Price, access & features
| Detail | RxSpan MD | Sesame Care |
|---|---|---|
| Luna Fit Score | 81/100 · B− | 85/100 · B |
| Overall rank | #19 | #4 |
| Semaglutide | $249/mo month-to-month (3/6/12-month prepay: $219/$199/$194 per month, billed $657/$1,194/$2,327 up front) | Care $59/mo only on the 12-month prepay, otherwise $99 billed every 28 days (13 charges a year) — plus the drug: brand Wegovy pill from $149/mo at 1.5 and 4 mg only, $299/mo at 9 and 25 mg |
| Tirzepatide | $329/mo month-to-month (3/6/12-month prepay: $309/$289/$269 per month, billed $927/$1,734/$3,228 up front) | Care $59/mo on the 12-month prepay, otherwise $99 per 28 days — plus the drug: brand Zepbound vial $299/mo (2.5 mg), $399 (5 mg), $449 (7.5–15 mg); KwikPen $299 / $399 / $499 / $699 (10–15 mg) |
| Coverage | All 50 states | Nationwide marketplace |
| Brand-name access | Yes | Yes |
| Oral / sublingual | Yes | Yes |
Luna Fit
RxSpan MD
Ranked #19 · Grade B−
What we like
- Four dispensing pharmacies named outright, with phone numbers — Belmar, Strive, Epiq Scripts and Casa Pharma Rx — where most of this ranking says only "our partner pharmacies"
- The prescribing group is named too, and checkable: Lion MD, led by Dr Ana Lisa Carr, MD (NPI 1689841744) with Dr Kelly Tenbrink, MD (NPI 1346482684). Both resolve as active physicians in the federal NPPES registry
- A real brand-name lane with prices on the page rather than an enquiry form — Ozempic $1,299, Wegovy $1,349 and Zepbound $1,069 a month — alongside the compounded line, so switching does not mean switching provider
The caveats
- The plan selector arrives with the 3-month prepay already chosen, not Monthly, and badges the 3-, 6- and 12-month tiers alike as "Max Saving" — so the default path takes $657 up front rather than $249, and the headline figures are footnoted "(For the first month)"
- Its FAQ says "no long-term commitments" on the same site where the 12-month semaglutide plan is a single $2,327 charge and the 12-month tirzepatide plan is $3,228. The freedom is real on the monthly plan; it is not what the prepay tiers are
- Brand-name bundles carry a $50 medical review fee if a clinician does not end up prescribing for you — worth knowing before you start an intake for Wegovy or Zepbound
Luna Fit
Sesame Care
Ranked #4 · Grade B
What we like
- Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
- Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
- You choose the provider and see the price up front — genuine marketplace transparency
The caveats
- A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
- Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
- Brand-name cash prices can run high without insurance
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. Pricing, states and verification reflect each provider's public disclosures at last review; the Luna Fit Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.
More head-to-heads
Neither RxSpan MD nor Sesame Care is only worth comparing with the other. RxSpan MD is also written up against CoreAge Rx, 12 points apart on the Luna Fit Score — see the RxSpan MD–CoreAge Rx head-to-head. Sesame Care is also written up against CoreAge Rx, 8 points apart — see Sesame Care against CoreAge Rx, factor by factor.
- RxSpan MD vs CoreAge Rx
- RxSpan MD vs Enhance MD
- RxSpan MD vs yourEra
- Sesame Care vs HealthRX
- Sesame Care vs MadeMed
- Sesame Care vs Trimi
Or browse the full comparison hub.